University of Toledo chemists discover how blue light speeds blindness

0
Ajith Karunarathne, Ph.D., assistant professor in the University of Toledo Depatment of Chemistry and Biochemistry. (Photo: utoledo.edu)

According to optical chemistry research team at the University of Toledo, Ohio, which includes a scientist of Sri-lankan origin, Blue light from digital devices and the sun transforms vital molecules in the eye’s retina into cell killers.

Ajith Karunarathne, Ph.D., assistant professor in the UT Department of Chemistry and Biochemistry, examined toxic oxygen generation by retinal during blue light exposure.

“We are being exposed to blue light continuously, and the eye’s cornea and lens cannot block or reflect it,” Karunarathne is quoted saying in s press release on the university website. “It’s no secret that blue light harms our vision by damaging the eye’s retina. Our experiments explain how this happens, and we hope this leads to therapies that slow macular degeneration, such as a new kind of eye drop,” he added.

The process outlined in the study, which was recently published in the journal Scientific Reports, leads to age-related macular degeneration, a leading cause of blindness in the United States, the press release said.

Macular degeneration, an incurable eye disease that results in significant vision loss starting on average in a person’s 50s or 60s, is the death of photoreceptor cells in the retina. Those cells need molecules called retinal to sense light and trigger a cascade of signaling to the brain.

“You need a continuous supply of retinal molecules if you want to see,” Karunarathne said. “Photoreceptors are useless without retinal, which is produced in the eye.”

Karunarathne’s lab found that blue light exposure causes retinal to trigger reactions that generate poisonous chemical molecules in photoreceptor cells, the press release said.

“It’s toxic. If you shine blue light on retinal, the retinal kills photoreceptor cells as the signaling molecule on the membrane dissolves,” Kasun Ratnayake, a PhD student researcher working in Karunarathne’s cellular photo chemistry group, said. “Photoreceptor cells do not regenerate in the eye. When they’re dead, they’re dead for good,” Ratnayake added.

Karunarathne introduced retinal molecules to other cell types in the body, such as cancer cells, heart cells and neurons. When exposed to blue light, these cell types died as a result of the combination with retinal. Blue light alone or retinal without blue light had no effect on cells.

“No activity is sparked with green, yellow or red light,” Karunarathne said. “The retinal-generated toxicity by blue light is universal. It can kill any cell type.”

According to the press release, “the researcher found that a molecule called alpha tocopherol, a vitamin E derivative and a natural antioxidant in the eye and body, stops the cells from dying. However, as a person ages or the immune system is suppressed, people lose the ability to fight against the attack by retinal and blue light.”

“That is when the real damage occurs,” Karunarathne is quoted saying.

The lab currently is measuring light coming from television, cell phone and tablet screens to get a better understanding of how the cells in the eyes respond to everyday blue light exposure.

To protect your eyes from blue light, Karunarathne advises to wear sunglasses that can filter both UV and blue light outside and avoid looking at cell phones or tablets in the dark.

“Every year more than two million new cases of age-related macular degeneration are reported in the United States,” Karunarathne said. “By learning more about the mechanisms of blindness in search of a method to intercept toxic reactions caused by the combination of retinal and blue light, we hope to find a way to protect the vision of children growing up in a high-tech world.”

Karunarathne issued a clarification after his research got significant media attention, noting, “Our findings do not show that light from digital devises causes blindness!”

“We caution the public that our study does not show that light from mobile devises or other digital screens causes blindness. What we demonstrate is that, in the presence of the photoreceptor chromophore “retinal”, the molecules that photoreceptor cells in the eye utilize to sense light, blue light perturbs cell signaling and induces cells death,” Karunarathne says on his website.  “Whether blue light from mobile devises and digital screens induces similar toxicity levels is an unanswered question and is currently under investigation,” he clarified, adding, “Even if such a scenario is found, since the studies are done in cultured cells, that would not indicate that these devises can cause similar damages to the vision. Nevertheless, some literature reports suggest that removal of blue component from intense light can reduce vision damages.”

 

 

Share